Title: A randomized controlled trial of intranasal fentanyl versus intravenous morphine for analgesia in the prehospital setting Authors: A/Professor
نویسندگان
چکیده
150 words) Study Objective To compare intranasal fentanyl (INF) with intravenous morphine (IVM) for prehospital analgesia. Methods Randomized, controlled, open-label trial. Consecutive adult patients (n=258) requiring analgesia (Verbal Rating Score (VRS) >2/10 non-cardiac or >5/10 cardiac) were recruited. Patients received INF 180mcg +/2 doses of 60 mcg at ≥ 5 minute intervals, or IVM 2.5-5mg +/2 doses of 2.5-5mg at ≥ 5 minute intervals. The endpoint was the difference in baseline/destination VRS. Results Groups were equivalent (p=NS) for baseline VRS [mean (SD): INF 8.3 (1.7), IVM 8.1, (1.6)] and minutes to destination [mean (SD): INF 27.2 (15.5), IVM 30.6 (19.1)]. Patients had a mean (95%CI) VRS reduction of: INF 4.22 (3.74-4.71), IVM 3.57 (3.10-4.03), p=0.08. Higher baseline VRS (p<0.001), no methoxyflurane use (p<0.01), and back pain (p=0.02) predicted VRS reduction. Safety and acceptability were comparable. Conclusions There was no significant difference in the effectiveness of INF and IVM for prehospital analgesia. Intranasal fentanyl versus intravenous morphine 2 A randomized controlled trial of intranasal fentanyl versus intravenous morphine for analgesia in the prehospital setting
منابع مشابه
A randomized controlled trial of intranasal fentanyl vs intravenous morphine for analgesia in the prehospital setting.
STUDY OBJECTIVE The objective of the study was to compare intranasal fentanyl (INF) with intravenous morphine (IVM) for prehospital analgesia. METHODS This was a randomized, controlled, open-label trial. Consecutive adult patients (n = 258) requiring analgesia (Verbal Rating Score [VRS] >2/10 noncardiac or >5/10 cardiac) were recruited. Patients received INF 180 mug +/- 2 doses of 60 mug at >...
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